بهار 1389

Dmm021246 1389..1400

Plastic changes in synaptic properties are considered as fundamental for adaptive behaviors. Extracellular-signal-regulated kinase (ERK)mediated signaling has been implicated in regulation of synaptic plasticity. Ribosomal S6 kinase 2 (RSK2) acts as a regulator and downstream effector of ERK. In the brain, RSK2 is predominantly expressed in regions required for learning and memory. Lossof-funct...

Dmd051565 1389..1397

Recent observations revealed that humanUDP-glucuronosyltransferase (UGT) 2B10 catalyzes N-glucuronidation of amine-containing compounds. Knowledge of the substrate specificity and clinical significance of UGT2B10 is still limited. The purpose of this study was to expand the knowledge of UGT2B10 substrates and to evaluate its significance in drug clearance. Using recombinant UGT2B10, we found th...

متن کامل مجله + پیوست ها (بهار 1389)

متن کامل مجله + پیوست ها (بهار 1389)

متن کامل مجله + پیوست ها (بهار 1389)

Biol. Pharm. Bull. 28(8) 1389—1393 (2005)

quence of the production of excess free radicals, such as reactive oxygen species, and provides marked damage to the structure and function of cell membranes in various tissues. Particularly, the brain is susceptible to free radical insults because it contains a high concentration of easily peroxidizable polyunsaturated fatty acids, and is not particularly enriched in protective antioxidant enz...